The role of high frequency oscillations in memory and motor performance

Chen, Qiaoyu (2024). The role of high frequency oscillations in memory and motor performance. University of Birmingham. Ph.D.

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Abstract

While high frequency (in the gamma range) rhythmic sensory stimulation (RSS) mainly involves inhibitory interneurons responses, low frequency RSS drives pyramidal neurons (Cardin et al., 2009). Using high and very low frequency RSS, the current thesis explored the role of high-frequency oscillations in human episodic memory and sensorimotor synchronization (SMS). High frequency RSS was delivered by short movies. Although existing evidence suggesting the recruitment of inhibitory interneurons by high frequency RSS, our findings revealed nuanced modulations in both SSVEPs and memory performance. In contrast, low frequency appears to play a crucial role in facilitating long-distance communications and plasticity. Supporting this idea, using low frequency auditory RSS, the final study revealed a connection between the phase locking of beta bursts to slow rhythms and movement performance. Collectively, despite the distinct mechanism underlying high and low frequency RSS, this thesis sheds light on the potential of RSS in regulating brain activity. Future investigations that integrate techniques such as optogenetics, neuroimaging, and computational modelling could provide a multidimensional perspective and valuable insights into the application of RSS in both research and clinical fields.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):