On the transition from reconsolidation to extinction of contextual fear memories

Cassini, Lindsey de Freitas ORCID: 0000-0002-2102-7005 (2019). On the transition from reconsolidation to extinction of contextual fear memories. University of Birmingham. Ph.D.

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In this thesis we present three main studies, two regarding the transition of reconsolidation to extinction of contextual fear memories (Chapters II and III), and one on the mechanisms of reconsolidation under the synaptic tagging and capture (STC) perspective (Chapter IV). On the transition of reconsolidation to extinction, we observed a “null point” period between the parameters that induce reconsolidation and extinction of contextual fear memories, at which memory was insensitive to disruption by the amnesic agent MK-801, and some evidence for underlying STC mechanisms in the process of memory destabilization and reconsolidation. These findings reinforce and expand the hypothesis of a three-phase transition between reconsolidation and extinction of episodic-like memories and bring new insights on the different ways memory might be affected by reactivation and the mechanistic process involved

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Licence: All rights reserved
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Psychology
Funders: Other
Other Funders: CAPES, University of Birmingham
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
URI: http://etheses.bham.ac.uk/id/eprint/8938


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