Species variations in the metabolism of xenobiotics with particular reference to the marmoset (Gallithrix .jacchus)

Hall, Brian Edward (1979). Species variations in the metabolism of xenobiotics with particular reference to the marmoset (Gallithrix .jacchus). University of Birmingham. Ph.D.

Preview

Hall1979PhD.pdf
Text - Accepted Version
Available under License All rights reserved.
Download (45MB) | Preview

Abstract

Considerable species variations exist in the metabolism of xenobiotics3 consequently one of the most difficult problems in examining the safety of a drug for human use lies in finding a suitable animal model in which the toxicity and metabolism of the drug can be usefully examined. This thesis describes an investigation of some pathways of xenobiotic metabolism in the marmoset (Oallithrix .jacchus), a small primate known to be suitable as a model for man in the study of teratogenic effects of drugs but for which few detailed studies of drug metabolism have been reported. The biotransformations studied were mainly conjugation reactions involving the combination of xenobiotics with glycine, glucuronic acid and acetic acid. Mercapturic acid formation which involves an initial conjugation with glutathione was also examined. During this work techniques were devised for the oral dosing of the marmosets, for housing the animals under study in conditions allowing the separate collection of urine and faeces and for the collection of small serial samples of blood. The regular breeding by the adults made it possible to study drug metabolism in the neonates, novel methods being developed for this study.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):