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The neurocognitive consequences of non-functioning pituitary adenoma and its treatment

Tooze, Alana (2010)
Ph.D. thesis, University of Birmingham.

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Patients with pituitary adenoma often report problems with cognitive function. However, the current literature is inconsistent on the types of cognitive deficits that patients experience. Chapter 1 of this thesis reviews the current literature and the questions that are still unanswered concerning the cognitive function of this patient group. Chapter 2 outlines the methodology used to assess the neurocognitive function of a group of patients with non-functioning pituitary adenoma. Chapters 3, 4 and 5 report and discuss the results of this assessment for general intellectual functioning, memory and executive functions. Chapter 6 discusses the physiological correlates of these results and finally, Chapter 7 presents the first fMRI experiment used to assess both content and context abilities in this patient group. The results of this thesis suggest that patients have intact general intellectual functioning and executive functions, in the presence of relative immediate memory impairment. Having hormone levels outside the normal range are a better predictor of dysfunction than treatment received. This thesis does not implicate surgery or radiotherapy as having adverse consequences to patients’ neurocognitive functioning.

Type of Work:Ph.D. thesis.
Supervisor(s):Jones, Christopher and Toogood, Andrew and Gittoes, Neil
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Psychology
Subjects:RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
BF Psychology
Institution:University of Birmingham
ID Code:941
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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