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Characterisation of coronary arteries: mechanical testing and three-dimensional imaging

Burton, Hanna Elisabeth (2018)
Ph.D. thesis, University of Birmingham.

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Abstract

Coronary artery disease is the leading cause of death in the UK. The studies in this thesis aim to influence the design of new biomaterials and medical devices used to treat coronary artery disease through the characterisation of left anterior descending (LAD) coronary arteries.
The mechanical properties of arteries were quantified using dynamic mechanical analysis, at physiological relevant frequencies. The surface roughness of porcine LAD coronary arteries was quantitatively measured using optical, scanning electron (SEM) and atomic force microscopy at various magnifications to assess its multi-scale characteristics. Further, the effect of damage to surface roughness of biological tissue was investigated due to mechanical overloading and chemical processing, with a correction factor presented for the changes to surface roughness due to processing techniques associated with SEM.
This thesis found LAD arteries to be viscoelastic, with a frequency-dependent storage moduli that does not vary along the length of the artery. Processing of tissue caused a significant increase in surface roughness, which must be considered for different microscopy techniques. The dehydration process had a greater effect on surface roughness than mechanical damage. The mechanical and surface roughness properties presented in this thesis can be specified for biomaterials to replicate natural, healthy coronary arteries.

Type of Work:Ph.D. thesis.
Supervisor(s):Espino, Daniel
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Mechanical Engineering
Subjects:R Medicine (General)
TJ Mechanical engineering and machinery
Institution:University of Birmingham
ID Code:7967
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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