Hore, Katie (2011)
M.Res. thesis, University of Birmingham.
Biomaterials are non-viable substances formulated to interact with biological systems. An ideal biomaterial will be cytocompatible – it will not cause an adverse response in the body – and will have similar physical properties to the material it is replacing. Group 2 metal phosphates make good biomaterials as they are chemically similar to bone and teeth. The synthesis and structure of magnesium acid pyrophosphate, MgH\(_2\)P\(_2\)O\(_7\) is reported. Attempts to dope calcium and magnesium acid pyrophosphates with metal cations to alter their physical and biological properties are described. The properties of a material can be modified by producing a composite. The interactions between a naturally occurring polymer, polyhydroxybutrate and calcium polyphosphate were investigated to see if a composite could be formed. It was found that polyhydroxybutrate decomposed at too low a temperature for a calcium polyphosphate composite to occur. The small piezoelectric properties of bone may assist the healing of any damage. γ-calcium polyphosphate may exhibit a piezoelectric effect. To measure this aligned crystals are required. γ-calcium polyphosphate was synthesised in magnetic and electric fields in an attempt to produce alignment. Although it was found fields did affect the product, it has not so far been possible to quantify or explain this effect.
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