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The investigation of condensed phosphates of alkaline earth metals for use as biomaterials

Hore, Katie (2011)
M.Res. thesis, University of Birmingham.

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Abstract

Biomaterials are non-viable substances formulated to interact with biological systems. An ideal biomaterial will be cytocompatible – it will not cause an adverse response in the body – and will have similar physical properties to the material it is replacing. Group 2 metal phosphates make good biomaterials as they are chemically similar to bone and teeth. The synthesis and structure of magnesium acid pyrophosphate, MgH\(_2\)P\(_2\)O\(_7\) is reported. Attempts to dope calcium and magnesium acid pyrophosphates with metal cations to alter their physical and biological properties are described. The properties of a material can be modified by producing a composite. The interactions between a naturally occurring polymer, polyhydroxybutrate and calcium polyphosphate were investigated to see if a composite could be formed. It was found that polyhydroxybutrate decomposed at too low a temperature for a calcium polyphosphate composite to occur. The small piezoelectric properties of bone may assist the healing of any damage. γ-calcium polyphosphate may exhibit a piezoelectric effect. To measure this aligned crystals are required. γ-calcium polyphosphate was synthesised in magnetic and electric fields in an attempt to produce alignment. Although it was found fields did affect the product, it has not so far been possible to quantify or explain this effect.

Type of Work:M.Res. thesis.
Supervisor(s):Wright, Adrian
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Subjects:TP Chemical technology
QD Chemistry
Institution:University of Birmingham
ID Code:1686
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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