The development of light curable biomaterials with enhanced biocompatibility for orthopaedic surgery

Nicolae, Laura Cristina (2016). The development of light curable biomaterials with enhanced biocompatibility for orthopaedic surgery. University of Birmingham. Ph.D.

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Abstract

The majority of materials used for cemented joint replacement and bone augmentation contain polymethylmethacrylate (PMMA)-based materials. Although commercially available for more than 60 years, PMM-based cements suffer from shortcomings including: the requirement of mixing in surgery of its components, high setting time and formation of a fibrous scar at the bone-implant interface, which may lead to necrosis of surrounding soft and hard tissues and failure of the implant. Incorporation of various fillers has been used to improve the physical, mechanical and biocompatibility with soft and hard tissues of PMMA-based materials, although the formation of a fibrous scar still remains one of the biggest concerns regarding its possibility of integrating with the surrounding bone tissue. Alternative materials have been tested including calcium phosphate cements and bioceramics in an attempt to provide a more suitable material for bone repair compared with PMMA-based cements. This work used a PMMA-based material as a starting point to develop a material with enhanced physical and mechanical characteristics that integrated with surrounding bone without the formation of the fibrous scar at its interface with bone and soft tissues. This new material will be based on the incorporation of different types of bioactive glasses in dimethacrylate-based resins.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

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