Pancholi, Shriya A. (2015). Encapsulation of dried yeast cells as probiotics by tabletting. University of Birmingham. Ph.D.
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Pancholi15PhD.pdf
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Abstract
There is an increasing demand from the pharmaceutical and food industries for new probiotic products. Some yeast strains offer probiotic benefits, but it has not been possible to formulate them successfully into a tablet dosage form. Direct compression is regarded as the best technique for producing tablets containing dried yeast, however, the main challenge of tabletting a powder mixture containing yeast granules is the mechanical sensitivity of the cells. The objective of this work was to develop a rigid yeast tablet containing adequate numbers of viable yeast cells by optimizing the formulation to allow a relatively low compaction force to be used. In addition the mechanical properties of primary particles and granules were determined as an attempt to predict the compaction behaviour during tabletting. A tablet formulation was developed which exhibited tablets of an acceptable tensile strength. These tablets were further tested for friability, dissolution and storage stability to ensure it is fit for consumer use.
| Type of Work: | Thesis (Doctorates > Ph.D.) | |||||||||
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| Award Type: | Doctorates > Ph.D. | |||||||||
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| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | |||||||||
| School or Department: | School of Chemical Engineering | |||||||||
| Funders: | Biotechnology and Biological Sciences Research Council, Other | |||||||||
| Other Funders: | The University of Birmingham | |||||||||
| Subjects: | T Technology > TP Chemical technology | |||||||||
| URI: | http://etheses.bham.ac.uk/id/eprint/6015 |
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