Low mood in rare genetic syndromes associated with intellectual disability

Armitage, Phoebe Eloise (2024). Low mood in rare genetic syndromes associated with intellectual disability. University of Birmingham. Clin.Psy.D.

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Abstract

This thesis contains four chapters. The first chapter is a literature review that discusses a systematic review and meta-analysis on the prevalence of depression in genetic syndromes associated with intellectual disability. The pooled prevalence estimates of depression are reported in four genetic syndromes where there were five or more studies that reported the depression prevalence. The pooled prevalence rates ranged from 9% in Williams syndrome to 13% in 22q11.2 deletion syndrome. The methodological quality of studies is reported and the need for further research reporting the prevalence of depression in genetic syndromes is highlighted.

The second chapter describes an empirical research project on correlates and predictors of low mood in three genetic syndromes associated with intellectual disability: Cornelia de Lange syndrome; fragile X syndrome; and Rubinstein-Taybi syndrome. The study found differences in the correlates and predictors of low mood in each syndrome group, suggesting there might be syndrome specific pathways to low mood. The clinical implications of understanding correlates of low mood in people with genetic syndromes are discussed.

The third and fourth chapters are two press releases and provide a summary of the literature review and the empirical research paper, respectively.

Type of Work:

Thesis (Doctorates > Clin.Psy.D.)

Award Type:

Doctorates > Clin.Psy.D.

Supervisor(s):