Investigations into parthenolide and boronic acid oxidation towards prodrug development

Quy, Alexander S. (2023). Investigations into parthenolide and boronic acid oxidation towards prodrug development. University of Birmingham. Ph.D.

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Abstract

Cancer is one of the leading causes of death worldwide. Current chemotherapy treatments display off-target effects leading to side effects. Through exploiting the intrinsic differences between healthy cells and cancerous cells, more targeted
therapies can be developed using boronic ester oxidation chemistry. Examined in this work are the efforts made into understanding the fundamentals of boronic ester oxidation chemistry, ultimately to inform design of cancer therapy prodrugs. For a starting lead compound, as many drugs on the market are derived from natural products, this work also discusses the scope for using parthenolide as a leukaemia therapy.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):