Investigations into parthenolide and boronic acid oxidation towards prodrug development

Quy, Alexander S. (2023). Investigations into parthenolide and boronic acid oxidation towards prodrug development. University of Birmingham. Ph.D.

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Abstract

Cancer is one of the leading causes of death worldwide. Current chemotherapy treatments display off-target effects leading to side effects. Through exploiting the intrinsic differences between healthy cells and cancerous cells, more targeted therapies can be developed using boronic ester oxidation chemistry. Examined in this work are the efforts made into understanding the fundamentals of boronic ester oxidation chemistry, ultimately to inform design of cancer therapy prodrugs. For a starting lead compound, as many drugs on the market are derived from natural products, this work also discusses the scope for using parthenolide as a leukaemia therapy.

Supporting information for the thesis can be accessed https://edata.bham.ac.uk/966/

Type of Work:	Thesis (Doctorates > Ph.D.)
Award Type:	Doctorates > Ph.D.
Supervisor(s):	Supervisor(s) Email ORCID Davies, Paul UNSPECIFIED UNSPECIFIED Agathanggelou, Angelo UNSPECIFIED UNSPECIFIED Tucker, James UNSPECIFIED UNSPECIFIED
Licence:	All rights reserved
College/Faculty:	Colleges > College of Engineering & Physical Sciences
School or Department:	School of Chemistry
Funders:	None/not applicable
Subjects:	Q Science > Q Science (General) Q Science > QM Human anatomy R Medicine > RZ Other systems of medicine
URI:	http://etheses.bham.ac.uk/id/eprint/14260

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