Application of remote ischaemic preconditioning to human coronary artery bypass surgery

843 28 2063 5 2971 document 2063 Rachman10MD.pdf application/pdf 64524a245a92eb0b623b2abc0613ac62 MD5 9819423 2011-07-19 16:24:13 http://etheses.bham.ac.uk//id/eprint/843/1/Rachman10MD.pdf 843 1 1 application/pdf application/pdf en public

Rachman10MD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8269 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8269 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/8269 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8270 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8270 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/8270 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8273 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8273 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/8273 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/13292 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/13292 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/13292 2066 6 2974 document 2066 Decl_IS_Rachman10MD.pdf application/pdf 1cc961d8672ea6f955f542b7a326d666 MD5 100356 2011-07-19 16:24:14 http://etheses.bham.ac.uk//id/eprint/843/2/Decl_IS_Rachman10MD.pdf 843 2 2 application/pdf application/pdf en staffonly

Decl_IS_Rachman10MD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8271 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8271 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/8271 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8272 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8272 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/8272 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/8274 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/8274 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/8274 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/13293 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/13293 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/13293 8269 2 10659 document 8269 small.png image/png 2e931751dbc7aa7584abb975062a9004 MD5 2663 2011-07-19 22:08:10 http://etheses.bham.ac.uk//id/eprint/843/3/small.png 843 3 3 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en public

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2063 8270 2 10660 document 8270 preview.jpg image/jpeg 5ac8f8848797b8c7bc1325ce473dbf5f MD5 9707 2011-07-19 22:08:11 http://etheses.bham.ac.uk//id/eprint/843/4/preview.jpg 843 4 4 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en public

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2063 8271 2 10662 document 8271 small.png image/png 6288633f40ad686973bd5a5c4001aebf MD5 11166 2011-07-19 22:08:11 http://etheses.bham.ac.uk//id/eprint/843/5/small.png 843 5 5 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en staffonly

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2066 8272 2 10663 document 8272 preview.jpg image/jpeg 7ca31ef4905d5cc0a092a6c1c29ff37f MD5 45866 2011-07-19 22:08:12 http://etheses.bham.ac.uk//id/eprint/843/6/preview.jpg 843 6 6 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en staffonly

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2066 8273 2 10664 document 8273 indexcodes.txt text/plain b6a172feea2efe434ec5c9dddb70b7a4 MD5 55923 2011-07-19 22:08:18 http://etheses.bham.ac.uk//id/eprint/843/7/indexcodes.txt 843 7 7 text/plain indexcodes Generate index codes conversion from application/pdf to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/2063 8274 2 10665 document 8274 indexcodes.txt text/plain 6a269f562e4d1f4918e8921c75a64bbe MD5 1575 2011-07-19 22:08:18 http://etheses.bham.ac.uk//id/eprint/843/8/indexcodes.txt 843 8 8 text/plain indexcodes Generate index codes conversion from application/pdf to indexcodes en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/2066 13292 2 19161 document 13292 preview.png image/png de4fad9aab53c1ca04087136384b8e8a MD5 9238 2011-07-21 10:49:47 http://etheses.bham.ac.uk//id/eprint/843/9/preview.png 843 9 9 image/png image/png en public

preview.png

http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2063 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2063 13293 2 19164 document 13293 preview.png image/png b416a351c1f563de67eda3f72a93f7d1 MD5 45645 2011-07-21 10:49:47 http://etheses.bham.ac.uk//id/eprint/843/10/preview.png 843 10 10 image/png image/png en staffonly

preview.png

http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2066 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2066 archive 4031 disk0/00/00/08/43 2010-07-12 11:29:52 2019-01-23 09:52:58 2011-07-19 16:24:13 thesis show 0 Rahman Ishtiaq Ali Bonser Robert Stuart Frenneaux Michael University of Birmingham Application of remote ischaemic preconditioning to human coronary artery bypass surgery unpub R1 RD RC 10col_mede This thesis reports a clinical study designed to assess myocardial, renal and lung outcomes following cardiac surgery. In a single centre, prospective randomized, placebo intervention-controlled trial the effects of intermittent upper limb ischaemia (remote ischaemic preconditioning (RIPC)) were compared in non-diabetic adult patients undergoing on-pump multi-vessel coronary artery surgery. Patients, investigators, anaesthetists, surgeons and critical care teams were all blind to group allocation. Subjects were randomized(1:1) to RIPC(or placebo) stimuli (3x upper limb (or dummy arm) 5 minute cycles of 200mmHg cuff inflation/deflation) during sternotomy and conduit procurement. Anaesthesia, perfusion, cardioplegia and surgical techniques were standardized. Groups were well matched on demographic and operative variables. In contrast to prior smaller studies, RIPC did not reduce troponin T (48 hour area under the curve (AUC); 6hour and peak) release, improve post-operative haemodynamics (cardiac indices; low cardiac output episodes incidence; IABP usage; inotrope and vasoconstrictor use; M mode, 2D contrastenhanced echocardiography and tissue Doppler imaging) or offer antiarrhythmic benefit (de novo left bundle branch block or Q waves; ventricular tachyarrhythmia incidence). RIPC did not afford renal (peak creatinine, AUC urinary albumin-creatinine ratios, dialysis requirement) or lung protection (intubation times, 6hour and 12 hour pO2/FiO2 ratios). Case urgency did not influence RIPC effect. 2010-07 2010-01 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 309 University of Birmingham School of Clinical and Experimental Medicine h_md FALSE british_heart_foundation 2010-07 graduation