Behavioural adjuvants to vaccination

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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2034 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2034 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2034 archive 4031 disk0/00/00/08/30 2010-07-06 08:44:33 2019-01-23 09:52:56 2011-07-19 16:24:02 thesis show 0 Campbell John P University of Birmingham Behavioural adjuvants to vaccination unpub GV RA0421 10col_life This thesis investigated the effects of acute eccentric exercise on the immune response to vaccination in young humans. Study one investigated whether the efficacy of the eccentric exercise intervention was affected by manipulating the timings of exercise prior to influenza vaccination. Three exercise groups were vaccinated immediately, 6 hr or 48 hr after exercise and antibody responses at 28 days post-vaccination were compared to those from a resting control group. All participants exhibited robust antibody responses to the vaccine and no effect of exercise was observed; therefore, it was not possible to determine the effects of exercise timing on vaccine responses. Study two investigated whether the antibody response to influenza vaccination was influenced by the intensity of eccentric exercise. Three groups exercised at an intensity eliciting 60%, 85% or 110% of one repetition maximum, and the antibody responses at 28 days post-vaccination were compared to those from a resting control group. In the exercise groups, both men and women showed enhanced antibody responses against the B/Florida strain, and men had enhanced responses against A/Uruguay, in comparison to resting controls. In both cases, the control group exhibited poorer responses against these strains, but no effect of exercise intensity was observed. Study three investigated whether the site of vaccine administration affected the efficacy of the immune response to hepatitis B vaccination following eccentric exercise. The antibody seroconversion rate to the vaccine was low (approx. 5 %), and thus, further analysis between exercise and control participants was not feasible. In sum, supporting previous research, it appears that acute eccentric exercise can enhance the immune response to poorly immunogenic strains of influenza, but research is needed to establish if exercise can enhance other poorly immunogenic vaccines, or vaccine responses in the immuno-compromised. 2010-07 2009-12 graduation eng This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 137 University of Birmingham School of Sport, Exercise and Rehabilitation Sciences d_ph na 2010-07 graduation