Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues

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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/1992 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/1992 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/1992 archive 4031 disk0/00/00/08/15 2010-07-07 08:38:09 2019-01-23 09:52:54 2011-07-19 16:23:46 thesis show 0 Onyimba Claire Uchechukwu Rauz Saaeha Walker Elizabeth University of Birmingham Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues unpub RE QR180 10col_mede The eye is a glucocorticoid target tissue which orchestrates expression of target genes through the glucocorticoid receptor (GR). The classical function of GR involves its interaction with glucocorticoid to influence transcription of genes involved in numerous physiological processes which include inflammation. The first line of defence in the ocular tissues includes the mucosal barrier and expression of receptors that recognise pathogen. These mechanisms activate the innate immune response during inflammation, however, in the ‘normal’ eye, immunomodulatory components exist to promote immune privilege. 11beta hydroxysteroid dehydrogenase 1 (11β-HSD1) regulates cortisol locally in tissues and has already been localised to to some ocular surface and intraocular tissues. The aim of this thesis is to evaluate the functional role of 11β-HSD1 in the eye and the orbit and whether the 11β-HSD1 can be targeted to modify various disease processes in the eye. An animal model was used to characterise the pre-receptor regulation of glucocorticoids and this was further characterised in human ocular and orbital tissues and cells. The results showed that 11β-HSD1 is functional in certain ocular (corneal epithelial, fibroblast and conjunctival fibroblast) and orbital (orbital preadipocyte) cells. The data therefore emphasises the putative role of 11β-HSDs in the ocular and orbital microenvronment. 2010-07 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 263 University of Birmingham School of Immunity and Infection d_ph FALSE na 2010-07 graduation