Using repeated measures of blood biomarkers and physical biomeasures to define changes in volume status in patients with decompensated heart failure, normal volunteers and patients with stable left ventricular systolic dysfunction

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/21863 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/21863 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/21863 archive 4031 disk0/00/00/36/17 2012-07-31 12:59:13 2019-01-23 09:56:40 2012-07-31 12:59:13 thesis show 0 Ng Kam Chuen Marie Jennyfer MacFadyen Robert J. Lip Gregory Y. H. University of Birmingham Using repeated measures of blood biomarkers and physical biomeasures to define changes in volume status in patients with decompensated heart failure, normal volunteers and patients with stable left ventricular systolic dysfunction unpub QH301 QP RC 10col_mede Background The non-invasive assessment of volume status in left ventricular systolic dysfunction (LVSD) is challenging. The main thesis objective was to establish the feasibility and potential clinical utility of repeated measures assessment of non-invasive biomarkers in defining changes in volume status within individual volunteers. Methods Differential volume manipulation protocols were achieved in a three-staged plan of investigation[…] Results Summary I demonstrated the smallest variance for bioimpedance measures, and the largest variance for urine biomarkers […] Conclusion The repeated measures of biomarkers studied in response to different volume manipulations were interpreted in the context of their within-subject normal variance. None of the biomarkers studied appeared to have the ideal characteristics clinically for the monitoring of subclinical changes in volume status in stable LVSD or in response to acute diuresis in decompensated heart failure. The significant increases in urine biomarkers following diuretic withdrawal in stable LVSD suggested potentially beneficial renal effects of furosemide in stable LVSD. 2012-12 2012 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 300 University of Birmingham School of Clinical and Experimental Medicine, Centre for Cardiovascular Sciences h_md na 2012-12 graduation