Functional, cognitive and emotional outcomes after transient Ischaemic attack: a systematic review and controlled cohort study

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/21799 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/21799 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/21799 archive 4031 disk0/00/00/36/08 2012-07-26 13:33:18 2019-01-23 09:56:39 2012-07-26 13:33:18 thesis show 0 Brittle Nicola Gwen University of Birmingham Functional, cognitive and emotional outcomes after transient Ischaemic attack: a systematic review and controlled cohort study unpub BF RC0321 10col_mede Introduction: As neurological symptoms of transient ischaemic attack (TIA) subside, it is assumed that patients return to their “normal” health state. The aim of this thesis was to examine whether this is assumption is true by studying psychological well-being, cognitive functioning and physical functioning after TIA. Methods: A systematic review was conducted to amalgamate and critique existing literature on health outcomes after TIA. A longitudinal, controlled cohort study was subsequently designed to develop the evidence base further and examine interaction effects between cognition, feelings of affect and physical function in all patients referred to TIA clinics. Results: Evidence to date suggests that patients diagnosed with TIA have more cognitive impairment and depression than “healthy” controls. Discussion: It is unclear how much of the observed association between cerebrovascular disease and cognitive dysfunction is mediated by cardiovascular risk factors, and/or whether TIA has a direct causal relationship. Regardless, such deficits could impact of the patient’s overall quality of life and their ability to absorb information aimed at reducing stroke risk. Further research should be directed at assessing the feasibility of screening patients for cognitive impairment and depression after referral to TIA clinics, and developing/evaluating interventions to facilitate patients whose screen is positive. 2012-12 2012-05 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 181 University of Birmingham School of Health and Population Sciences, Primary Care Clinical Sciences m_ph na 2012-12 graduation