Sleep and its association with metabolic function across the lifespan

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/19796 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/19796 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/19796 archive 2795 disk0/00/00/33/43 2012-05-25 10:36:51 2019-01-23 09:56:05 2012-05-25 10:36:51 thesis show 0 Arora Teresa Taheri Shahrad University of Birmingham Sleep and its association with metabolic function across the lifespan unpub QH301 10col_mede Obesity and accompanied metabolic dysfunction are global public health problems. A better understanding of factors contributing to obesity and metabolic disease development is needed, particularly lifestyle behaviours including sleep. Sleep duration has been suggested to be a contributor to obesity and metabolic dysfunction development. This thesis examines the relationships between sleep, obesity, and metabolic function in different age groups and ethnicities. The thesis also presents a model for experimental sleep manipulation that can be used to understand the underlying mechanisms for the associations among sleep duration, obesity, and metabolic dysfunction. The studies and findings were as follows: 1. Cross-sectional data from young South Asian children in Birmingham showed that ‘inadequate' sleep duration, unlike findings from different population studies, was not associated with overweight/obesity. 2. Cross-sectional data from a population of adolescents in the Midlands showed that short sleep duration was associated with increased odds of overweight/obesity. 3. Cross-sectional data from older Chinese from Guangzhou, China, showed that total long sleep duration was associated with increased odds of the metabolic syndrome. 4. Data from the experimental sleep model revealed that reducing sleep over a prolonged period is more achievable than sleep extension. 2012-07 2011-09 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 333 University of Birmingham School of Clinical and Experimental Medicine d_ph na 2012-07 graduation