An investigation of basic science and clinical research methodologies to benefit clinical practice

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/743 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/743 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/743 archive 4031 disk0/00/00/03/06 2009-10-26 12:05:55 2019-01-23 09:51:53 2011-07-19 16:15:33 thesis show 0 Varma Rajesh rajesh.varma@gstt.nhs.uk University of Birmingham An investigation of basic science and clinical research methodologies to benefit clinical practice unpub R1 RG 10col_mede The aim of this PhD thesis was to produce research that could inform and benefit clinical practice by exploring the application of basic science and clinical research methodologies to disorders in obstetrics and gynaecology. Chapter 1’s investigation of endometriosis is the first to 1) report detailed genetic mapping of endometriosis-associated ovarian cancer, 2) report the existence of micro-LOH (loss of heterozygosity) in ovarian endometriosis through a SNP 100K DNA array. Chapter 2 explores the efficacy of interventions to treat menstrual abnormalities using clinical cohort studies. Furthermore, Chapter 2 highlights how negligence in female sterilization failure may be mathematically (Bayesian) modelled. Chapter 3 explores the value of systematic reviews for preventing preterm delivery and use of LNG-IUS (Mirena coil). The clinical guidelines published in Chapter 4 include: vaginal birth after previous caesarean, ectopic pregnancy, safe laparoscopic entry and minimising risk of sterilisation failure. The thesis concludes (Chapter 5) by suggesting strategies to augment the research methodological approaches evaluated in this thesis in order fulfill the aim of benefitting clinical practice. Work included in this PhD thesis has been orally presented at international conferences, published in peer-reviewed journals, and published as a national clinical guideline by the Royal College of Obstetricians and Gynaecologists, UK (RCOG). 2009-07-13 2008-12-19 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. The Academy of Medical Sciences Royal College of Obstetricians and Gynaecologists public 502 University of Birmingham School of Clinical and Experimental Medicine, Academic Department of Obstetrics and Gynacology d_ph FALSE other 2009-07-13 graduation