Lymphostromal interactions in the development and function of thymic epithelial cells

2902 12 15844 6 26533 document 15844 Roberts11PhD.pdf application/pdf 83913201b7fc8256e582e76fc5456e1b MD5 5544732 2011-11-04 14:47:06 http://etheses.bham.ac.uk//id/eprint/2902/1/Roberts11PhD.pdf 2902 1 1 application/pdf application/pdf en public

Roberts11PhD.pdf

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/15844 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/15844 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/15844 archive 4031 disk0/00/00/29/02 2011-11-04 14:49:14 2019-01-23 09:55:05 2011-11-04 14:49:14 thesis show 0 Roberts Natalie Amy Anderson Graham Jenkinson Eric ftp://ubira.bham.ac.uk/eTheses/2902_Roberts/ University of Birmingham Lymphostromal interactions in the development and function of thymic epithelial cells unpub QM RC 10col_mede The thymus is a primary lymphoid organ that supports the production, differentiation and selection of self-tolerant T cells from immature precursors of extrathymic origin. T cell development is a dynamic process involving the movement of thymocytes through specialised regions of the thymus, each directing distinct developmental stages. The formation of these microenvironments is crucial for providing the ordered and continuous signalling required to drive the non-cell autonomous process of T cell development. The development of thymocytes and thymic epithelial cells (TEC) are interdependent processes involving reciprocal signalling termed “thymic crosstalk”. Using novel in vitro and in vivo experimental techniques we elucidated novel processes in the regulation of thymic epithelial cell development. We corroborated the importance of thymic crosstalk by revealing a new role for innate like  T cells in influencing medullary thymic epithelial cell development. Furthermore, this study argues against a specific time frame for the occurrence of thymic crosstalk by demonstrating that adult thymic epithelium retains its receptivity to lymphostromal signalling. In addition, we have recognised the importance of intrathymic niches in regulating early T cell progenitor development. Collectively these data have provided an insight into the development of the thymic epithelium and thus have important implications in relation to developing rejuvenation strategies for the atrophied thymus and following ablative therapy. 2011-07 2010-10 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 336 University of Birmingham Institute of Biomedical Research, Department of Anatomy d_ph na 2011-07 graduation