Rhodium(III) supramolecular complexes: synthesis, DNA binding and biological studies

2814 17 14920 6 23976 document 14920 Vitorino11PhD.pdf application/pdf af3877846a9b891fccf712b166ba7ef7 MD5 14627422 2011-08-04 11:47:39 http://etheses.bham.ac.uk//id/eprint/2814/1/Vitorino11PhD.pdf 2814 1 1 application/pdf application/pdf en public

Vitorino11PhD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/14924 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/14924 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/14924 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/14925 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/14925 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/14925 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/14926 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/14926 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/14926 14921 4 23979 document 14921 Decl_IS_Vitorino11PhD.pdf application/pdf 5723e52a28c49a7bd5903f51438d4fe9 MD5 172380 2011-08-04 11:47:50 http://etheses.bham.ac.uk//id/eprint/2814/2/Decl_IS_Vitorino11PhD.pdf 2814 2 2 application/pdf application/pdf en staffonly

Decl_IS_Vitorino11PhD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/14922 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/14922 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/14922 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/14923 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/14923 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/14923 14922 2 23989 document 14922 small.png image/png be676ac20fc989adb9f66d3556aa6f48 MD5 8176 2011-08-04 13:46:54 http://etheses.bham.ac.uk//id/eprint/2814/3/small.png 2814 3 3 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en staffonly

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/14921 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/14921 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/14921 14923 2 23990 document 14923 preview.jpg image/jpeg a19fa617609e9112815297b04a0298ec MD5 33836 2011-08-04 13:46:54 http://etheses.bham.ac.uk//id/eprint/2814/4/preview.jpg 2814 4 4 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en staffonly

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/14921 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/14921 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/14921 14924 2 23991 document 14924 small.png image/png 2ff430f55c3b1cd3ee7eaffafc6f78be MD5 5351 2011-08-04 13:46:55 http://etheses.bham.ac.uk//id/eprint/2814/5/small.png 2814 5 5 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en staffonly

small.png

preview.jpg

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/14920 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/14920 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/14920 archive 4031 disk0/00/00/28/14 2011-08-04 12:04:12 2019-01-23 09:54:53 2011-08-04 12:04:12 thesis show 0 Vitorino Susana Ricardo Hannon Michael J. University of Birmingham Rhodium(III) supramolecular complexes: synthesis, DNA binding and biological studies unpub QD QM QR RC0254 10col_ephy The work described in this thesis concerns the synthesis, DNA binding and cytotoxicity studies of new Rh(III) supramolecular complexes. Chapter 1 reviews DNA molecular recognition by synthetic agents; exploring the different DNA binding modes and their importance in the anticancer properties of several metallodrugs. Special attention is given to the exciting cylinder agents, which underpin the work in this thesis and to the work with rhodium complexes and their studies with DNA and as anticancer drugs. Chapter 2 describes the synthesis, purification and characterization of Rh(III) mononuclear, dinuclear single, double and triple stranded complexes. NMR, MS, UV‐Vis, elemental analyses and in some cases X‐ray crystallography are discussed in detail. In Chapter 3, DNA binding properties of the Rh(III) complexes are explored by CD and LD spectroscopy. Gel Electrophoresis experiments are also carried out using plasmid DNA (pBR322). The dinuclear complexes are found to bind to ct‐DNA and to have more dramatic effects than the mononuclear analogues. In addition they were found to cleave plasmid DNA. Chapter 4 presents cytotoxicity studies for some of the complexes synthesized against breast and ovarian cancer cell lines. A PCR study with the Rh(III) double stranded isomers is also carried out demonstrating that these complexes are able to inhibit and block DNA transactions as represented by PCR DNA replication. 2011-07 2011-02 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. The University of Birmingham public 271 University of Birmingham School of Chemistry d_ph european_commission other 2011-07 graduation