Psychosocial and psychophysiological characteristics of atrial fibrillation patients and their influence on the prothrombotic state and prognosis

246 28 608 8 878 document 608 Thrall06PhD.pdf application/pdf 9848c7d6721d9ac53a76d1dafab64b0f MD5 5066959 2011-07-19 16:14:38 http://etheses.bham.ac.uk//id/eprint/246/1/Thrall06PhD.pdf 246 1 1 application/pdf application/pdf en public

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/608 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/608 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/608 archive 4031 disk0/00/00/02/46 2009-06-24 08:36:45 2019-01-23 09:51:46 2011-07-19 16:14:38 thesis show 0 Thrall Graham ftp://ubira.bham.ac.uk/eTheses/246_Thrall/ University of Birmingham Psychosocial and psychophysiological characteristics of atrial fibrillation patients and their influence on the prothrombotic state and prognosis unpub R1 RC1200 40fac_sci Atrial fibrillation; Rate and rhythm-control interventions; Quality of life Appendix I is not available in this web version. Appendix II is a published paper: Graham Thrall, Deirdre Lane, Douglas Carroll, Gregory Y.H. Lip, Quality of Life in Patients with Atrial Fibrillation: A Systematic Review, The American Journal of Medicine, Volume 119, Issue 5, May 2006, Pages 448.e1-448.e19, ISSN 0002-9343, http://dx.doi.org/DOI:10.1016/j.amjmed.2005.10.057 Tables in chapter 1 are in a different order compared with the printed copy. The purpose of this thesis was to (1) examine the psychological morbidity associated with atrial fibrillation (AF), and (2) determine the effects of acute mental and postural stress, and hydration status on indices haemorhelogy, endothelial function, and platelet reactivity. Symptoms of depression (BDI scores > 10) persisted in 38% of patients with AF, with elevated state and trait anxiety (STAI score >40) being reported in 28% and 38% of patients, respectively. No significant differences in depression, state anxiety, and QoL were observed between AF and hypertensive patients; however, AF patients displayed higher levels of trait anxiety. Multiple regression analysis demonstrated baseline depression scores provided the best independent prediction of future QoL. Acute mental and postural stress yielded significant changes in haemodynamics and haemorhelogy, in addition to increasing biomarkers of endothelial dysfunction and platelet reactivity. Increased hydration status reduced blood pressure and markers of endothelial perturbation and platelet morphology both at rest and in response to the stress tasks. In conclusion, AF patients display comparable levels of depression and anxiety to patients following a myocardial infarction. In addition, behavioural activities such as mental and postural stress may implicated in the pathogenesis of acute coronary syndromes through the development of a prothrombotic state. 2006-12-13 2006-08 graduation 2610654 eng author checked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 211 University of Birmingham Sport & Exercise Sciences d_ph FALSE na 2006-12-13 graduation