Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control

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http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/49 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/49 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/49 archive 4031 disk0/00/00/00/22 2007-09-14 16:52:18 2019-01-23 09:51:23 2011-07-19 16:11:52 thesis show 0 Solomon Thomas Phillip James Blannin Andrew University of Birmingham Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control unpub RC1200 QP 30sch_spex insulin, ghrelin, lipemia, feeding frequency The metabolic syndrome is highly prevalent in western society, and the numbers affected by obesity and diabetes continue to rise. This thesis reviews the mechanisms at play and the gaps in the literature that, if filled, may increase knowledge of treatment regimes for affected individuals. Experimentally, it was demonstrated that the oral glucose tolerance test can be a reliable tool to measure insulin sensitivity following adequate dietary and exercise control. Acute and chronic cinnamon ingestion was shown to improve insulin sensitivity. Feeding frequency was found to alter insulin and ghrelin responses and relationships following mixed-meal ingestion. And finally, postprandial lipaemia was found to be attenuated for up to 24 hours following moderate-intensity exercise, illustrating the requirement of daily exercise. In summary, oral glucose tolerance tests are suitable for experimental interventions; and the clinical management of factors associated with the metabolic syndrome should perhaps consider dietary supplements, meal frequency, and exercise timing in addition to the traditional dietary and physical activity guidelines currently in practice. 2007-07 graduation 2631817 eng author checked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 129 University of Birmingham School of Sport, Exercise and Rehabilitation Sciences d_ph na 2007-07 graduation