Gold-catalysed cycloisomerisations of ketoalkynes

1740 26 42791 7 100234 document 42791 Detty-Mambo_11_PhD.pdf application/pdf cb622205d1b46e376012cf5441a9661d MD5 3739582 2015-05-01 09:05:58 http://etheses.bham.ac.uk//id/eprint/1740/5/Detty-Mambo_11_PhD.pdf 1740 5 4 application/pdf application/pdf en public

Detty-Mambo_11_PhD.pdf

accepted http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/42792 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/42792 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/42792 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/42793 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/42793 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/42793 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/42796 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/42796 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/42796 42793 2 100239 document 42793 preview.jpg image/jpeg 7d4eb316e0c12f9a455d9764866554e1 MD5 13651 2015-05-01 09:06:53 http://etheses.bham.ac.uk//id/eprint/1740/7/preview.jpg 1740 7 7 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en staffonly

preview.jpg

small.png

Decl_IS_Detty-Mambo_Post_Embargo.pdf

other http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/42794 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/42794 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/42794 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/42795 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/42795 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/42795 42794 2 100240 document 42794 small.png image/png b92369f84ad6b9a870eb08b68b2092f2 MD5 11808 2015-05-01 09:06:54 http://etheses.bham.ac.uk//id/eprint/1740/8/small.png 1740 8 8 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en staffonly

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/42790 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/42790 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/42790 42795 2 100241 document 42795 preview.jpg image/jpeg f6589571fb963c76c67681b908da309c MD5 54315 2015-05-01 09:06:54 http://etheses.bham.ac.uk//id/eprint/1740/9/preview.jpg 1740 9 9 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en staffonly

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/42790 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/42790 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/42790 42796 2 100242 document 42796 indexcodes.txt text/plain 87871dc8dc90e41e6c014477e822a288 MD5 34990 2015-05-01 09:06:57 http://etheses.bham.ac.uk//id/eprint/1740/10/indexcodes.txt 1740 10 10 text/plain indexcodes Generate index codes conversion from application/pdf to indexcodes en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/42791 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/42791 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/42791 archive 4031 disk0/00/00/17/40 2011-09-28 10:03:45 2019-01-23 09:54:46 2011-09-28 10:03:45 thesis show 0 Detty-Mambo Christelle Davies Paul ftp://epr-staff@ubira.bham.ac.uk/eTheses/Embargoes_strictly_CONFIDENTIAL/DettyMambo_1740_expires30April2015/ University of Birmingham Gold-catalysed cycloisomerisations of ketoalkynes unpub QD 10col_ephy After embargo expires (30/4/2015) treat as option C until 30/04/2016 The direct cyclisation between alkynes and ketones was described by Conia in 1964. Under high temperatures (150-650 °C), alkynyl and alkenyl ketones were converted into carbocycles, bis-fused carbocycles and spiro compounds by a pericyclic ene-type reaction. However, the use of elevated temperatures limits its applications to thermally robust molecules. Since the original report, a significant amount of effort has been made to develop alternative approaches under mild conditions. These methods employ activated methylenes, frozen enol equivalents or enamine intermediates as nucleophiles in the presence of a Lewis acid (Hg, W, Pt, Au) to activate the unsaturated moiety. Although, synthetically useful, these processes are limited by the necessity to use a preformed enol or a co-catalyst, which involves additional synthetic steps and reagents. 2011-07 2010-11 graduation eng This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 332 University of Birmingham School of Chemistry d_ph na 2011-07 graduation