Analysis of biological pathways, associated with orthodontic force, using multiplex arrays

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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/3750 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/3750 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/3750 archive 4031 disk0/00/00/16/35 2011-06-20 15:29:49 2019-01-23 09:54:33 2011-07-19 16:39:28 thesis show 0 Wilson Jay Louise Chapple Iain L. (Iain Leslie) Rock Peter University of Birmingham Analysis of biological pathways, associated with orthodontic force, using multiplex arrays unpub RK 10col_mede Objective - investigate tissue changes induced by orthodontic forces at tension and compression sites. Methods - Gingival Crevicular Fluid (GCF), was collected from maxillary canines and second molars from volunteers (n=21), before appliance placement and tooth extraction (B); 3 months into orthodontic treatment (T1); at 4 hours (T2); 1 week (T3); and 6 weeks (T4) after application of a canine distalising force. Periodontal health, plaque scores, canine movement and GCF volumes were recorded. Cytokines (GM-CSF, IFN, IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF), tissue (MMP-9, TIMP-1 and 2) and bone metabolism (RANKL, OPG) biomarkers were measured. Results –IL-1β, IL-8, TNFα, MMP-9 increased in canine tension sites and TIMPs 1 and 2 from T2-T4, canine compression sites showed increases in IL-1β and IL-8 only at T2, MMP-9 at T3 and T4 and RANKL at T4. GCF volume increased T2 - T4, but plaque and periodontal measures did not. Conclusions - Significant changes in the profile of several biomarkers consistant with tissue remodelling were seen. Differences between tension and compression sites were not statistically significant. TNFα, GM-CSF, IL-1β, IL-8 correlated with the rate of tooth movement. MMP-9, TIMP-1, TIMP-2 correlated with tooth movement 4 hours after the distalising force was applied. 2011-07 2010-10 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 188 University of Birmingham School of Dentistry m_ph na 2011-07 graduation