Oxidative stress biomarkers in dementia

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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/3470 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/3470 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/3470 archive 4031 disk0/00/00/14/49 2011-03-16 15:28:47 2019-01-23 09:54:12 2011-07-19 16:36:27 thesis show 0 Bennett Stuart James University of Birmingham Oxidative stress biomarkers in dementia unpub RC1200 RA0421 10col_life Research from this thesis is published in: Bennett,S., Grant,M.M., and Aldred,S. (2009). Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology. J. Alzheimers Dis. Jun; 17(2):245-57. DOI: 10.3233/JAD-2009-1041 Aldred,S., Bennett,S., and Mecocci,P. (2010). Increased low density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clin. Biochem. Feb;43(3):267-71. Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approaches. Results presented in this thesis suggest that global plasma protein oxidation levels are not different when AD and control subjects are compared, but that individual plasma proteins are specific targets for oxidative modification in AD. The thesis explores different methodologies to assess oxidative changes in AD. In addition it demonstrates that emerging novel and powerful mass spectrometry techniques can be employed successfully to identify several proteins modified by oxidation, providing an initial starting point for further investigation. 2011-07 2010-10 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 259 University of Birmingham School of Sport, Exercise and Rehabilitation Sciences d_ph FALSE na 2011-07 graduation