Supramolecular anticancer agents and their effects on cells and biomolecules

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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/3293 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/3293 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/3293 archive 4031 disk0/00/00/13/36 2011-02-17 08:54:13 2019-01-23 09:53:57 2011-07-19 16:33:28 thesis show 0 Pope Alexandra Jayne Hannon Michael J. University of Birmingham Supramolecular anticancer agents and their effects on cells and biomolecules unpub QD RC0254 QM 10col_ephy Metallo-drugs have been highly significant in the development of novel anticancer agents. Supramolecular drug agents allow the design and synthesis of a range of molecular architectures. The work in this thesis has built upon previous knowledge on this subject by undertaking novel biological studies on known metal supramolecular helicates as well as the design of a new helicate in order to improve upon existing drugs. In chapter three, the DNA three-way junction binding of a number of supramolecular cylinders is described. Three-way junction binding is a new mode of DNA recognition and relevant to the DNA replication fork, present in dividing cells. Chapter four outlines a number of novel in vitro studies on an iron supramolecular cylinder which indicate new, unsuspected and unprecedented biological actions. In chapter five biological studies of unsaturated ruthenium(II) helicates are discussed. These complexes combine a cisplatin like coordinative binding mode with a helical supramolecular design. Chapter six discusses the design of a synthetic route from an unsaturated ruthenium(II) complex to create a novel supramolecular compound with a tuneable ligand surface. 2011-07 2011-02 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 198 University of Birmingham School of Chemistry d_ph na 2011-07 graduation