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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2660 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2660 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2660 archive 4031 disk0/00/00/12/86 2011-01-06 14:02:18 2019-01-23 09:53:51 2011-07-19 16:28:39 thesis show 0 Duprey Jean-Louis Henry Alan Tucker James University of Birmingham unpub QD 10col_ephy This thesis describes the synthesis, characterization and study of a range of oligonucleotides that were modified by the inclusion of a non-nucleosidic anthracene unit. This involved the synthesis of different stereoisomers of a non-nucleosidic backbone attached to DNA via a carbon chain linker. These monomers were then coupled to short (15-mer) oligonucleotide chains using solid state DNA synthesis and purified using RP-HPLC. Two systems were studied: a duplex with anthracene functioning as a non-bonding base opposite of a natural nucleobase and a wedge type system. The probes were then examined by a variety of physical techniques that included UV melting point studies, fluorescence and CD spectroscopy in order to understand the effect of varying base pairs and introducing mismatches. Certain duplexes were then studied in greater depth using transient absorption spectroscopy, to probe the formation of electron transfer intermediates and by high field NMR to look at the effect of intercalation between base pairs. In order to aid explanation of the acquired data, molecular modeling studies were undertaken using AMBER and the University of Birmingham Bluebear cluster to produce solvated, molecular dynamics optimized structures. The formation of excimers in bis-anthracene systems as potential precursors to photo-ligated DNA duplexes was also studied. 2011-12 2010-09 graduation eng This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. ubira@lists.bham.ac.uk public 397 University of Birmingham School of Chemistry d_ph na 2011-12 graduation