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http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2829 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2829 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2829 archive 4031 disk0/00/00/11/28 2010-11-24 16:14:41 2019-01-23 09:53:32 2011-07-19 16:29:52 thesis show 0 Oo Ye Htun y.h.oo@bham.ac.uk Adams David Walker Lucy University of Birmingham unpub QR180 10col_mede Regulatory T cells, Th17, Tc17, Chemokines, Recruitment, Liver inflammation The liver is a unique tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by adjusting either hepatic tolerance or mounting immunity against invading pathogens. Thus, it is important to understand the intrahepatic regulatory T cells phenotype and role played by distinct chemokine receptors expressed on regulatory T cells as they are major player in controlling hepatic tolerance. At the same time, it would be crucial to explore the role of new subset of Th17/Tc17 effector lymphocytes characteristic and their positioning in inflamed liver. This thesis demonstrates the crucial role of chemokine receptors in recruitment and positioning of both intrahepatic regulatory T lymphocytes and IL-17 secreting Th17/Tc17 effector lymphocyte in both normal and inflamed human liver. 2010-12 2010 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. Ye Htun Oo public 312 University of Birmingham School of Immunity and Infection d_ph mrc 2010-12 graduation