Development and validation of a diagnostic tool for occupational asthma based on serial lung function measurements

1094 35 2727 5 3910 document 2727 Moore10PhD.pdf application/pdf a39b694746a6bf5f893428be15c0e41d MD5 8124989 2011-07-19 16:29:12 http://etheses.bham.ac.uk//id/eprint/1094/3/Moore10PhD.pdf 1094 3 1 application/pdf application/pdf en public

Moore10PhD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/2744 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/2744 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/2744 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/2746 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/2746 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/2746 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/7144 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/7144 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/7144 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/13680 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/13680 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/13680 2728 6 3911 document 2728 Decl_IS_Moore10PhD.pdf application/pdf cf501d45193df2d38bc692b35204122c MD5 94566 2011-07-19 16:29:12 http://etheses.bham.ac.uk//id/eprint/1094/2/Decl_IS_Moore10PhD.pdf 1094 2 4 application/pdf application/pdf en staffonly

Decl_IS_Moore10PhD.pdf

http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/2737 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/2737 http://eprints.org/relation/hassmallThumbnailVersion http://etheses.bham.ac.uk/id/document/2737 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/2740 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/2740 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/2740 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/7145 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/7145 http://eprints.org/relation/hasIndexCodesVersion http://etheses.bham.ac.uk/id/document/7145 http://eprints.org/relation/hasVolatileVersion http://etheses.bham.ac.uk/id/document/13681 http://eprints.org/relation/haspreviewThumbnailVersion http://etheses.bham.ac.uk/id/document/13681 http://eprints.org/relation/hasVersion http://etheses.bham.ac.uk/id/document/13681 2737 2 3925 document 2737 small.png image/png 1135babcbe4341004dc1d8f4508cd84c MD5 11319 2011-07-19 16:29:18 http://etheses.bham.ac.uk//id/eprint/1094/4/small.png 1094 4 4 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en staffonly

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2728 2740 2 3929 document 2740 preview.jpg image/jpeg ed655a928fa3c7448c3b30cb7355e80e MD5 45775 2011-07-19 16:29:18 http://etheses.bham.ac.uk//id/eprint/1094/5/preview.jpg 1094 5 5 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en staffonly

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2728 2744 2 3934 document 2744 small.png image/png 10c62a32cf11fe72b982d1752459c797 MD5 3156 2011-07-19 16:29:20 http://etheses.bham.ac.uk//id/eprint/1094/6/small.png 1094 6 6 image/png thumbnail_small Thumbnail Documents conversion from application/pdf to thumbnail_small en public

small.png

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/issmallThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2727 2746 2 3937 document 2746 preview.jpg image/jpeg 56bb9d23d0df0647c2f2bd433a8ad870 MD5 11892 2011-07-19 16:29:20 http://etheses.bham.ac.uk//id/eprint/1094/7/preview.jpg 1094 7 7 image/jpeg image/jpeg Thumbnail Documents conversion from application/pdf to thumbnail_preview en public

preview.jpg

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2727 7144 2 9391 document 7144 indexcodes.txt text/plain 797f29613688079bd2d7cae5744f0e80 MD5 32918 2011-07-19 20:16:54 http://etheses.bham.ac.uk//id/eprint/1094/8/indexcodes.txt 1094 8 8 text/plain indexcodes Generate index codes conversion from application/pdf to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/2727 7145 2 9392 document 7145 indexcodes.txt text/plain 807ba3fd9ac354386010b055d759aecd MD5 1579 2011-07-19 20:16:56 http://etheses.bham.ac.uk//id/eprint/1094/9/indexcodes.txt 1094 9 9 text/plain indexcodes Generate index codes conversion from application/pdf to indexcodes en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/isIndexCodesVersionOf http://etheses.bham.ac.uk/id/document/2728 13680 2 20327 document 13680 preview.png image/png 3b1eb626cc12ef246010adc126a5b737 MD5 9387 2011-07-21 10:52:17 http://etheses.bham.ac.uk//id/eprint/1094/10/preview.png 1094 10 10 image/png image/png en public

preview.png

http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2727 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2727 13681 2 20330 document 13681 preview.png image/png cedd2bd0e6a4ceb3b43d08fa5a9a994b MD5 45338 2011-07-21 10:52:17 http://etheses.bham.ac.uk//id/eprint/1094/11/preview.png 1094 11 11 image/png image/png en staffonly

preview.png

http://eprints.org/relation/isVolatileVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/ispreviewThumbnailVersionOf http://etheses.bham.ac.uk/id/document/2728 http://eprints.org/relation/isVersionOf http://etheses.bham.ac.uk/id/document/2728 archive 4031 disk0/00/00/10/94 2010-11-29 17:34:39 2019-01-23 09:53:29 2011-07-19 16:29:12 thesis show 0 Moore Vicky Clare University of Birmingham Development and validation of a diagnostic tool for occupational asthma based on serial lung function measurements unpub RA0421 10col_mede Serial peak expiratory flow measurements (PEF) are recommended as an initial investigation in the confirmation of occupational asthma. Plotting measurements in Oasys gives reproducible results and can be used by non-experts. I report a new analysis, the area between curves (ABC) score, which gives 72% sensitivity and 100% specificity using a cut off of 15 L/min/h. Two-hourly measurements of PEF require 8 work days and 3 rest days for sensitive and specific analysis. Serial PEF records with long periods off work (≥ 4 consecutive days) show improved sensitivity from 73% to 80%, implying that 7 more workers in every 100 would be diagnosed. In a comparison of forced expiratory volume in one second (FEV1) to PEF, PEF was more sensitive to diurnal changes than FEV1, although FEV1 was more reproducible. Exhaled breath nitric oxide (FENO) showed similar ABC scores between those with normal and raised FENO. FENO was significantly correlated to methacholine reactivity. In shift workers, mean ABC scores were increased on morning shifts compared to nights, but the cut off of 15 L/min/h would be applicable across all shift types. The ABC score is a new robust method of confirming occupational asthma requiring shorter records than the Oasys score. 2010-12 2010-08 graduation eng author unchecked This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. public 233 University of Birmingham School of Health and Population Sciences, Primary Care Clinical Sciences d_ph na 2010-12 graduation