Two case studies of SPH modelling in biological system: large intestine and deep vein valves

Wen, Wei (2018). Two case studies of SPH modelling in biological system: large intestine and deep vein valves. University of Birmingham. M.Phil.

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Computational Fluid Dynamics (CFD) techniques has proven its adaptiveness and mutuality in various application for diversified fields. At the moment, the investigation of physical mechanics developed by CFD in physiological transportation has arisen great attention. This thesis aims at deepening the insight into the interactive mechanism between the periodic deformable human conduits and the conveyed fluid content. To start with a coupled method consists of Smoothed Particle Hydrodynamics (SPH) method and Coarse-Grained Molecular Dynamics (CGMD) I Mass-spring modelling (MSM) is adopted as it has proven its potentials in dealing with the transportation inside the deformable solid boundaries. The fluid part is simply simulated by the SPH method while the soft solid boundaries are mimicked by another one to yield the optimal utility of the coupled method. Our models developed for Gastric Intestine (GI) system are first validated by comparisons with PET experimental outcomes and are applied to the practical usage. Quantitative analysis is made among simulations to illustrate the mixing and transportation of food propelled by the muscle peristalsis. Then the method is further extended into the study of the venous system and the results indicate a good interpretation of the pathological study of the valve dysfunction and the venous development.

Type of Work: Thesis (Masters by Research > M.Phil.)
Award Type: Masters by Research > M.Phil.
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Chemical Engineering
Funders: None/not applicable
Subjects: T Technology > TP Chemical technology


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