CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation

Riddell, Natalie E. (2010). CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation. University of Birmingham. Ph.D.


Download (1MB)


This thesis investigated the effect of acute psychological stress and \(\beta\)-adrenergic receptor (\(\beta\)AR) stimulation on the mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(\beta\)AR- sensitivity increases in parallel with greater effector functions and cell differentiation. As Cytomegalovirus (CMV) infection influences CD8TL differentiation, Chapter 3 compared the mobilization of cytotoxic lymphocytes in CMV seropositive and seronegative individuals; CMV infection enhanced the stress reactivity of CD8TLs, CD4TLs and NKT-like cells. Chapter 4 examined whether antigen-specificity could modulate CD8TL stress- and \(\beta\)AR-sensitivity. CMV-specific cells demonstrated enhanced mobilization compared to the total-memory CD8TL and the total Epstein-Barr virus (EBV) population. In Chapter 5, we demonstrated that PC subsets, capable of both replenishing leukocyte populations and maintaining endothelial integrity, were also mobilized by acute psychological stress. This result was not replicated by \(\beta\)ARagonist infusion suggesting the involvement of \(\alpha\)AR or non-adrenergic mechanism. In sum, the current findings suggest that stress mobilization serves to protect the host by increasing immune protection and tissue repair mechanisms. However, such a response may also be detrimental dependent on the circumstance, i.e., infection versus inflammation.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Sport, Exercise and Rehabilitation Sciences
Funders: None/not applicable
Subjects: R Medicine > RC Internal medicine
Q Science > QR Microbiology > QR180 Immunology
B Philosophy. Psychology. Religion > BF Psychology


Request a Correction Request a Correction
View Item View Item


Downloads per month over past year