Frailty, sarcopenia and immunesenescence: shared mechanisms and clinical insights

Wilson, Daisy (2018). Frailty, sarcopenia and immunesenescence: shared mechanisms and clinical insights. University of Birmingham. Ph.D.

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Frailty, the increased vulnerability of an individual to stressors, and sarcopenia, the loss of muscle mass with age, share many of the same clinical outcomes, associations and suggested pathophysiology. The pathophysiology of both conditions is incompletely characterised but it is postulated the immune system is central to development and propagation. 40 healthy young, 40 healthy older, and 37 frail older adults were recruited to three groups. A further 73 healthy young adults were recruited for ultrasound assessment of muscle.

Ultrasound was reviewed as a diagnostic technique in the identification of sarcopenia using a simple scanning protocol to produce the bilateral anterior thigh thickness (BATT). The BATT was measured in a reference population, 113 in total, and proposed criteria for the identification of low muscle mass in older adults was based on this reference population.

Neutrophils exhibit a frailty related decline in migratory accuracy towards chemoattractants; this was both independent of age and associated with physical and cognitive parameters of frailty. Incubation of neutrophils from frail older adults with PI3kinase inhibitors class 1A \(\delta\) and class lB y restored migratory accuracy and this presents a novel therapeutic target for management of frailty.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: Institute of Inflammation and Ageing
Funders: Versus Arthritis, Medical Research Council
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine


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