Sawbridge, Rebecca Joanne (2018). Developments in magnetic resonance spectroscopic imaging acquisition and analysis. University of Birmingham. Ph.D.
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Sawbridge18PhD.pdf
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Abstract
Magnetic Resonance Spectroscopic Imaging (MRSI), a functional MR imaging technique, has proven via the identification of metabolite biomarkers to be useful in the diagnosis and prognosis of numerous diseases, for example brain tumours. However, a number of factors impede its routine clinical use: i) long acquisition times mean its use is limited to low resolution 2-dimensional slabs, ii) large quantity of data produced means its interpretation can be time consuming and iii) data quality can be variable and therefore interpretation can be difficult for a non-expert. Further developments in MRSI are designed to reduce the impact of these issues. The focus of this work is to address some of the above issues; developing acquisition protocols and optimising analysis methods in order to increase the clinical feasibility of MRSI. Within this study a fast-MRSI protocol has been developed for absolute metabolite quantitation and has demonstrated its feasibility for clinical use, accurately reproducing data in a shorter clinically feasible acquisition time. An experimentally derived fitting model has been developed which increases metabolite measurement accuracy. Finally, a 3D MRSI protocol has been successfully optimized allowing robust metabolite information to be mapped throughout the brain.
Type of Work: | Thesis (Doctorates > Ph.D.) | ||||||||||||
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Award Type: | Doctorates > Ph.D. | ||||||||||||
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College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | ||||||||||||
School or Department: | School of Chemistry | ||||||||||||
Funders: | Engineering and Physical Sciences Research Council, National Institute for Health Research | ||||||||||||
Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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URI: | http://etheses.bham.ac.uk/id/eprint/8050 |
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