The natural history of impaired glucose regulation amongst young adults and its effect on renal function

Jadhakhan, Ferozkhan (2017). The natural history of impaired glucose regulation amongst young adults and its effect on renal function. University of Birmingham. Ph.D.

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Introduction: The risk of chronic kidney disease (CKD) aith impaired glucose regulation (IGR) is not well characterised. It is not clear whether individuals with IGR are at risk of developing CKD or whether the risk is confined to individuals who progressed to overt diabetes.

Methods: This study consists of three main parts: 1) systematic review, 2) analysis to determine incidence and prevalence of IGR, and 3) analysis to determine risk of CKD in IGR. A systematic review was undertaken using a large dataset of patient records to describe the incidence and prevalence of IGR and to investigate the relationship between IGR and CKD.

Results: The systematic review found no evidence associating risk of CKD in young adults aged 18 to 40 years with IGR. The THIN database analysis shows that incidence and prevalence increased consistently throughout the study period. Incidence of CKD was 4 times higher in IGR than normoglycaemia. The incidence of CKD stage (3-5) was approximately 4 times higher than the incidence of CKD stage (1-2) in the IGR cohort.

Conclusion: The systematic review demonstrates that the risk of CKD in young adults with IGR remains to be elucidated. The THIN database analyses provides evidence of an increased risk of CKD amongst young adults with IGR. It also showed that IGR patients are at higher risk of CKD stage (3-5) compared to CKD stage (1-2).

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: School of Health and Population Sciences, Primary Care Clinical Sciences
Funders: National Institute for Health Research, Other
Other Funders: The University of Birmingham
Subjects: Q Science > QH Natural history > QH301 Biology


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