Interleukin-1α as a biomarker of human abdominal aortic aneurysm (AAA) development and progression

Ahmad, Mehtab (2017). Interleukin-1α as a biomarker of human abdominal aortic aneurysm (AAA) development and progression. University of Birmingham. M.D.

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Abstract

This Thesis presents an analysis of the role of interleukin (IL)-1α (IL-1α) as a potential future surrogate biomarker for AAA. It is the only research work to date to have looked into the role of IL-1α as a biomarker in AAA disease, correlating titres with different anatomical, morphological and patient-related factors. It is the first piece, in over 20 years of published literature, to have performed a robust methodology study on the measurement of IL-1a in serum samples using different techniques. A comparison study of commercially available immunoassays in the context of IL-1α has never been undertaken before, and we are the first to undertake one. Additionally the work on the natural history of AAA is one of the largest single-centre cohort studies to analyse AAA growth in surveillance.
The work covers three main areas: identifying why current strategies for monitoring AAA are ineffective, analysis of different serum processing methodologies and commercially available immunoassays used to measure IL-1α, and linking IL-1α to different anatomical, morphological and patient-related AAA factors.

Type of Work: Thesis (Higher Doctorates > M.D.)
Award Type: Higher Doctorates > M.D.
Supervisor(s):
Supervisor(s)EmailORCID
Bradbury, AndrewUNSPECIFIEDUNSPECIFIED
Vohra, RajivUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: Institute of Cardiovascular Sciences
Funders: None/not applicable
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Q Science > QR Microbiology > QR180 Immunology
URI: http://etheses.bham.ac.uk/id/eprint/7712

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