The germinal centre artificial immune system

Joshi, Ayush (2017). The germinal centre artificial immune system. University of Birmingham. Ph.D.

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This thesis deals with the development and evaluation of the Germinal centre artificial immune system (GC-AIS) which is a novel artificial immune system based on advancements in the understanding of the germinal centre reaction of the immune system. The key research questions addressed in this thesis are: can an artificial immune system (AIS) be designed by taking inspiration from recent developments in immunology to tackle multi-objective optimisation problems? How can we incorporate desirable features of the immune system like diversity, parallelism and memory into this proposed AIS? How does the proposed AIS compare with other state of the art techniques in the field of multi-objective optimisation problems? How can we incorporate the learning component of the immune system into the algorithm and investigate the usefulness of memory in dynamic scenarios? The main contributions of the thesis are:

• Understanding the behaviour and performance of the proposed GC-AIS on multiobjective optimisation problems and explaining its benefits and drawbacks, by comparing it with simple baseline and state of the art algorithms.

• Improving the performance of GC-AIS by incorporating a popular technique from multi-objective optimisation. By overcoming its weaknesses the capability of the improved variant to compete with the state of the art algorithms is evaluated.

• Answering key questions on the usefulness of incorporating memory in GC-AIS in a dynamic scenario.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department: School of Computer Science
Funders: None/not applicable
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QA Mathematics > QA76 Computer software
Q Science > QR Microbiology > QR180 Immunology


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