A study of gut hormones in type 1 diabetes

Hughes, David Simon (2017). A study of gut hormones in type 1 diabetes. University of Birmingham. Ph.D.

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Type 1 diabetes (DMT1) is a chronic autoimmune disease that leads to apoptosis and death of pancreatic islet beta cells. These beta cells are influenced by and contribute to a network of gut derived hormones that regulate glucose homeostasis. Our research explores the effect that DMT1 has on this network of gut hormones. A series of clinical research studies was established to collect samples from both healthy participants and individuals with DMT1. Methods to measure gut hormones were explored and refined prior to sample analysis. Results from this analysis revealed that the homeostasis of glucagon, active-ghrelin and peptide YY are affected by DMT1 and that glucagon secretion may be controlled by a glucose independent signal derived from the gut. Important lifestyle markers in DMT1 were identified and included a correlation between leptin and body mass index and gastric inhibitory polypeptide and sedentary behaviour. Histopathological analysis of pancreatic slides taken from donors with DMT1 suggest that the islet area stained for glucagon does not correlate with duration of diabetes, but does correlate with age. Together these suggest that type 1 diabetes does affect other gut hormones involved in glucose homeostasis and this can be influenced by lifestyle factors.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: Institute of Clinical Sciences
Funders: None/not applicable
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
URI: http://etheses.bham.ac.uk/id/eprint/7529


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