# Developing nucleophilic nitrenoids for the synthesis of complex heterocycles

Garzon Sanz, Miguel (2016). Developing nucleophilic nitrenoids for the synthesis of complex heterocycles. University of Birmingham. Ph.D.

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## Abstract

The combination of nucleophilic nitrenoids and gold-catalysis has rapidly emerged as a powerful tool in the assembling of different nitrogen-containing motifs. The research presented in this thesis describes the advances in the field and the exploration of pyrimidium $$N$$-heteroaryl aminides as building blocks in the formation of several fused imidazoheterocycles.
From the initial discovery of this reaction and its application in the synthesis of imidazo[1,2-a]pyrimidines, the scope of this convergent gold-catalysed strategy has been adapted to allow the access to fourteen classes of biologically relevant structures. The proposed mechanism and optimisation will be discussed alongside the accommodation of a wide range of useful functionalities difficult to introduce by other methodologies.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Davies, PaulUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department: School of Chemistry
Funders: Other
Other Funders: The University of Birmingham
Subjects: Q Science > QD Chemistry
URI: http://etheses.bham.ac.uk/id/eprint/7060

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