Placental growth factor (PlGF) regulation and expression in endothelial cells

Lal, Niraja Padmalata (2016). Placental growth factor (PlGF) regulation and expression in endothelial cells. University of Birmingham. Ph.D.

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Abstract

The role of Placenta growth factor (PlGF) in physiological angiogenesis is quiescent, preclinical and human studies have established PlGF angiogenic activity to be regulated in pathologies. PlGF elicits its cellular functions via (vascular endothelial growth factor receptor) VEGFR-1 alone, and has gained more attention for its safety profile, especially when compared to the risks involved in VEGF-derived therapies. Loss and gain studies of PlGF function highlight the contribution of PlGF in disease aggravation or alleviation; however, factors regulating PlGF expression remains elusive.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Ahmed, AsifUNSPECIFIEDUNSPECIFIED
Hewett, PeterUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: School of Clinical and Experimental Medicine
Funders: British Heart Foundation
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine
URI: http://etheses.bham.ac.uk/id/eprint/6821

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