Novel functionalised, nanoarrays of DNA binding supramolecular helicates

White, Jenifer Christine (2016). Novel functionalised, nanoarrays of DNA binding supramolecular helicates. University of Birmingham. Ph.D.

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Work described in this thesis shows the design, synthesis, DNA binding activity and gold nanoparticle interaction of functionalised triple stranded supramolecular helicates. DNA structures and the way molecules recognise and bind to them are reviewed, with specific emphasis on supramolecular compounds.
Supramolecular helicates are discussed in detail with consideration of how they may be used as anticancer agents. Nanoparticles, specifically gold nanoparticles are studied, with specific reference to how they are able to enhance anticancer properties of drug molecules and how they may be used to develop potent anticancer therapies.
With the formation of three novel supramolecular iron helicates and the incorporation of supramolecular chemistry and nanotechnology, through binding such complexes to the surface of gold nanoparticles, foundations of work in this area are discussed, showing promising results for future research.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
College/Faculty: Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department: School of Chemistry
Funders: Other, Engineering and Physical Sciences Research Council
Other Funders: European Cooperation in Science and Technology, The University of Birmingham
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics


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