Takebayashi, Yuiko (2015). Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol. University of Birmingham. Ph.D.
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Takebayashi15PhD.pdf
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Abstract
Thiomarinol is a novel hybrid antibiotic produced by \(Pseudoalteromonas\) \(rava\) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency.
| Type of Work: | Thesis (Doctorates > Ph.D.) | |||||||||
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| Award Type: | Doctorates > Ph.D. | |||||||||
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| College/Faculty: | Colleges (2008 onwards) > College of Life & Environmental Sciences | |||||||||
| School or Department: | School of Biosciences | |||||||||
| Funders: | None/not applicable | |||||||||
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology |
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| URI: | http://etheses.bham.ac.uk/id/eprint/5562 |
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