Investigations of a possible novel decontamination role for a haemostatic product: studies with S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX)

Lydon, Helen Louise (2012). Investigations of a possible novel decontamination role for a haemostatic product: studies with S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX). University of Birmingham. Ph.D.

Preview

Lydon12PhD.pdf
PDF - Accepted Version
Download (2MB)

Abstract

Haemorrhage remains a leading cause of death in civilian and military environments. Recent research into emergency treatments for severe haemorrhaging injuries has resulted in production of a number of advanced haemostatic products. In certain scenarios, concomitant release of toxic materials may exacerbate trauma and ultimately reduce survival from such injuries. In particular, systemic absorption of the nerve agent VX (S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate) via wounds may rapidly cause muscle paralysis and death. This research explored the hypothesis that a haemostatic product could perform an additional function as a wound decontaminant.
[…]
In summary, this project has successfully demonstrated that haemostatic products, based on an adsorptive mechanism of action, offer a highly effective means of countering the rapidly fatal effects of the chemical warfare agent VX present in wounded skin tissue. Further development of the concept of a haemostatic decontaminant has life-saving implications.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

Supervisor(s):