The investigation of condensed phosphates of alkaline earth metals for use as biomaterials

Hore, Katie (2011). The investigation of condensed phosphates of alkaline earth metals for use as biomaterials. University of Birmingham. M.Res.


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Biomaterials are non-viable substances formulated to interact with biological systems. An ideal biomaterial will be cytocompatible – it will not cause an adverse response in the body – and will have similar physical properties to the material it is replacing. Group 2 metal phosphates make good biomaterials as they are chemically similar to bone and teeth. The synthesis and structure of magnesium acid pyrophosphate, MgH\(_2\)P\(_2\)O\(_7\) is reported. Attempts to dope calcium and magnesium acid pyrophosphates with metal cations to alter their physical and biological properties are described. The properties of a material can be modified by producing a composite. The interactions between a naturally occurring polymer, polyhydroxybutrate and calcium polyphosphate were investigated to see if a composite could be formed. It was found that polyhydroxybutrate decomposed at too low a temperature for a calcium polyphosphate composite to occur. The small piezoelectric properties of bone may assist the healing of any damage. γ-calcium polyphosphate may exhibit a piezoelectric effect. To measure this aligned crystals are required. γ-calcium polyphosphate was synthesised in magnetic and electric fields in an attempt to produce alignment. Although it was found fields did affect the product, it has not so far been possible to quantify or explain this effect.

Type of Work: Thesis (Masters by Research > M.Res.)
Award Type: Masters by Research > M.Res.
College/Faculty: Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department: School of Chemistry
Funders: None/not applicable
Subjects: T Technology > TP Chemical technology
Q Science > QD Chemistry


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