Mother-to-child transmission of SARS-CoV-2: review of reviews, systematic review and meta-analysis

Ansari, Kehkashan (2022). Mother-to-child transmission of SARS-CoV-2: review of reviews, systematic review and meta-analysis. University of Birmingham. M.Sc.

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Objective: To conduct a review of reviews on existing systematic reviews reporting on mother-to-child transmission (MTCT) of SARS-CoV-2 and to review the existing classification systems of MTCT. To assess the rates of SARS-CoV-2 neonatal positivity in babies born to SARS-CoV-2 infected mothers and the rate of vertical transmission if any and to determine the risk factors associated with offspring SARS-CoV-2 positivity.

Design: Review of reviews, Systematic review and meta-analysis.

Results: From the 68 included systematic reviews, the review of reviews was able to show the lack of use of a classification system to ascertain the timing of SARS-CoV-2 transmission. Systematic reviews need to consider previously published research to avoid data duplication and minimize research waste. The World Health Organization (WHO) classification system provides robust and detailed information to classify babies born to mothers with SARS-CoV-2 infection. Of the included 472 studies, the overall rate of babies born to mothers with SARS-CoV-2 infection was 1.8%. Fourteen babies out of 592 had confirmed mother-to-child transmission, with seven in utero, two intrapartum and five in early postnatal period.

Conclusion: High-quality systematic reviews are needed in order to synthesis evidence allowing the determination of the true extent of vertical transmission of SARS-CoV-2. The WHO standardised definition and categorisation system allows the evaluation of timing and routes of possible transmission. The rates of SARS-CoV-2 positivity are low in babies born to SARS-CoV-2 infected mothers. While there is evidence for vertical transmission, the occurrence is rare and the risk factors of neonatal positivity

Type of Work: Thesis (Masters by Research > M.Sc.)
Award Type: Masters by Research > M.Sc.
Licence: All rights reserved
College/Faculty: Colleges (2008 onwards) > College of Medical & Dental Sciences
School or Department: Institute of Metabolism and Systems Research
Funders: None/not applicable
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine


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