The synthesis and characterisation of novel supramolecular structures and their binding to DNA

Hooper, Catherine Amelia Josephine (2020). The synthesis and characterisation of novel supramolecular structures and their binding to DNA. University of Birmingham. M.Sc.

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Abstract

The aim of this thesis was to synthesise and characterise the DNA binding of novel structures based on a supramolecular cylinder. These structures are designed to retain the three way junction binding properties of the parent cylinder, while making modifications which have the potential to change DNA binding properties such as binding capacity, selectivity and control.

The first chapter provides and introduction to non-canonical DNA structures and the ligands which have been developed to bind them. In chapter 2, the synthesis of new supramolecular cylinders, a trinuclear helicate and an asymmetric helicate, is investigated. A method for post assembly modification of a cylinder analogue is developed in chapter 3, which is then used to synthesise the first rotaxane from a supramolecular helicate via the capping mechanism. These structures are analysed by mass spectrometry and NMR. Finally, the DNA binding of a cylinder analogue and the rotaxane is investigated using UV Visible spectroscopy, circular dichroism and linear dichroism in chapter 4.

Type of Work: Thesis (Masters by Research > M.Sc.)
Award Type: Masters by Research > M.Sc.
Supervisor(s):
Supervisor(s)EmailORCID
Hannon, Michael J.UNSPECIFIEDUNSPECIFIED
Hodges, NikUNSPECIFIEDUNSPECIFIED
Stewart, GrantUNSPECIFIEDUNSPECIFIED
Licence: All rights reserved
College/Faculty: Colleges (2008 onwards) > College of Engineering & Physical Sciences
School or Department: School of Chemistry
Funders: None/not applicable
Subjects: Q Science > QD Chemistry
URI: http://etheses.bham.ac.uk/id/eprint/10045

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