Interleukin-1α as a biomarker of human abdominal aortic aneurysm (AAA) development and progression

Ahmad, Mehtab (2017). Interleukin-1α as a biomarker of human abdominal aortic aneurysm (AAA) development and progression. University of Birmingham. M.D.

Preview

Ahmad17MD.pdf
PDF
Download (2MB)

Abstract

This Thesis presents an analysis of the role of interleukin (IL)-1α (IL-1α) as a potential future surrogate biomarker for AAA. It is the only research work to date to have looked into the role of IL-1α as a biomarker in AAA disease, correlating titres with different anatomical, morphological and patient-related factors. It is the first piece, in over 20 years of published literature, to have performed a robust methodology study on the measurement of IL-1a in serum samples using different techniques. A comparison study of commercially available immunoassays in the context of IL-1α has never been undertaken before, and we are the first to undertake one. Additionally the work on the natural history of AAA is one of the largest single-centre cohort studies to analyse AAA growth in surveillance.
The work covers three main areas: identifying why current strategies for monitoring AAA are ineffective, analysis of different serum processing methodologies and commercially available immunoassays used to measure IL-1α, and linking IL-1α to different anatomical, morphological and patient-related AAA factors.

Type of Work:

Thesis (Higher Doctorates > M.D.)

Award Type:

Higher Doctorates > M.D.

Supervisor(s):