White, Jenifer Christine (2016). Novel functionalised, nanoarrays of DNA binding supramolecular helicates. University of Birmingham. Ph.D.
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White16PhD.pdf
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Abstract
Work described in this thesis shows the design, synthesis, DNA binding activity and gold nanoparticle interaction of functionalised triple stranded supramolecular helicates. DNA structures and the way molecules recognise and bind to them are reviewed, with specific emphasis on supramolecular compounds.
Supramolecular helicates are discussed in detail with consideration of how they may be used as anticancer agents. Nanoparticles, specifically gold nanoparticles are studied, with specific reference to how they are able to enhance anticancer properties of drug molecules and how they may be used to develop potent anticancer therapies.
With the formation of three novel supramolecular iron helicates and the incorporation of supramolecular chemistry and nanotechnology, through binding such complexes to the surface of gold nanoparticles, foundations of work in this area are discussed, showing promising results for future research.
| Type of Work: | Thesis (Doctorates > Ph.D.) | ||||||
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| Award Type: | Doctorates > Ph.D. | ||||||
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| College/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences | ||||||
| School or Department: | School of Chemistry | ||||||
| Funders: | Other, Engineering and Physical Sciences Research Council | ||||||
| Other Funders: | European Cooperation in Science and Technology, The University of Birmingham | ||||||
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics |
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| URI: | http://etheses.bham.ac.uk/id/eprint/6625 |
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