Exploring changes in markers of oxidative stress and inflammation in response to exercise

Wadley, Alex James (2014). Exploring changes in markers of oxidative stress and inflammation in response to exercise. University of Birmingham. Ph.D.

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Abstract

Oxidative stress and inflammation are two reciprocally linked processes that characterise many disease states, but can also transiently increase in response to a range of stimuli, including exercise, to initiate adaptation. This thesis presents novel data indicating that oxidative stress did not increase in response to an acute mental arithmetic challenge, under resting conditions or experimentally induced high baseline inflammation. In the context of exercise, chapters 3, 4 and 5 support previous work that markers of plasma and peripheral blood mononuclear cell (PBMC) oxidative stress increase in response to acute exercise. Acute exercise (30-40 min, 70% VO2MAX) in rheumatoid arthritis patients caused a transient increase in protein carbonylation that over a period of training (3 months, 3 sessions per week) at the same intensity did not increase global oxidative stress or inflammation. Plasma 3-nitrotyrosine decreased with exercise training, alongside improvements in disease activity and aerobic fitness. The last two experimental chapters of this thesis explored acute changes in plasma (Chapter 4) and PBMC (Chapter 5) oxidative stress in response to bouts of low volume high intensity interval training (LV-HIIT) and steady state exercise (60% maximal oxygen consumption (VO2MAX), 27 minutes and 80% VO2MAX, 20 minutes). LV-HIIT provided an anti-inflammatory (IL-6 and IL-10) and anti-oxidant (plasma total antioxidant capacity and PBMC thioredoxin protein content) response to exercise that paralleled the response (magnitude and timecourse) observed with steady state exercise of high and moderate intensity.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

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