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Metallo-Supramolecular complexes and their interactions with biomolecules and cells

Banwait, Sukraj Kaur (2010)
Ph.D. thesis, University of Birmingham.

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Abstract

Chapter 1 introduces the field of supramolecular chemistry and reviews examples of supramolecular architectures. Applications of these assemblies are outlined with a focus on DNA recognition. In chapter 2 the synthesis and characterisation of an array of palladium(II) and platinum(II) tetra-stranded, dinuclear complexes is described. The synthesis of two palladium(II) triangles and a palladium(II) pyramid are also presented. Chapter 3 investigates the biological activities of four of the tetra-stranded palladium(II) complexes described in chapter 2. The results show that while all of them bind to DNA, only two show good cytotoxic activities in an MTT assay. Toxicological studies were conducted on the two active cylinders and excitingly, the preliminary results indicate that they are not genotoxic or mutagenic. In chapter 4 the interaction of two novel single-stranded palladium(II) and platinum(II) complexes with B-DNA is probed by circular and linear dichroism and gel electrophoresis. The study confirms that the complexes bind to DNA, causing it to kink and bend. Chapter 5 presents the synthesis and crystallographic characterisation of four new silver(I) supramolecular polymers. In chapter 6 a new pyridylazo ligand system is described and the coordination chemistry of this ligand with silver(I), copper(I) and palladium(II) investigated.

Type of Work:Ph.D. thesis.
Supervisor(s):Hannon, Michael J.
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Subjects:QD Chemistry
Institution:University of Birmingham
ID Code:964
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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