Novel encapsulation of water soluble active ingredients to acheive their controlled release in aqueous environment

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Sui, Cong (2019). Novel encapsulation of water soluble active ingredients to acheive their controlled release in aqueous environment. University of Birmingham. Ph.D.

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Abstract

Encapsulation technology has been widely researched and applied to different industry sectors. There are vast examples of encapsulation for controlled release of hydrophilic or hydrophobic ingredients to the target place. However, it is still difficult to encapsulate the small water-soluble salts or molecules, achieving long-term sustained release or even no release in water.

Herein, a novel type of organic-inorganic composite solid microsphere, comprised of polystyrene sulfonate and silica was developed here to achieve a sustained release of K+ ions in aqueous environment for over 48 hours. Furthermore, a novel type of melamine formaldehyde (MF) based has been developed to encapsulate KCl and allura red, showing a sustained release of KCl and allura red for 12 h and > 10 days in water, respectively. Finally, a novel formulation for encapsulation of KCl and allura red has been developed based on the formation of melamine formaldehydeoctadecyltrichlorosilane- melamine formaldehyde (MOM) microcapsules, achieving no release in aqueous environment for 1 month. It is a breakthrough to prevent the leakage of small water soluble ingredients from the carrier, which is of great significance for their long-term storage until they are delivered to a target place via triggered release in many applications.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

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