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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation

Riddell, Natalie E. (2010)
Ph.D. thesis, University of Birmingham.

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This thesis investigated the effect of acute psychological stress and \(\beta\)-adrenergic receptor (\(\beta\)AR) stimulation on the mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(\beta\)AR- sensitivity increases in parallel with greater effector functions and cell differentiation. As Cytomegalovirus (CMV) infection influences CD8TL differentiation, Chapter 3 compared the mobilization of cytotoxic lymphocytes in CMV seropositive and seronegative individuals; CMV infection enhanced the stress reactivity of CD8TLs, CD4TLs and NKT-like cells. Chapter 4 examined whether antigen-specificity could modulate CD8TL stress- and \(\beta\)AR-sensitivity. CMV-specific cells demonstrated enhanced mobilization compared to the total-memory CD8TL and the total Epstein-Barr virus (EBV) population. In Chapter 5, we demonstrated that PC subsets, capable of both replenishing leukocyte populations and maintaining endothelial integrity, were also mobilized by acute psychological stress. This result was not replicated by \(\beta\)ARagonist infusion suggesting the involvement of \(\alpha\)AR or non-adrenergic mechanism. In sum, the current findings suggest that stress mobilization serves to protect the host by increasing immune protection and tissue repair mechanisms. However, such a response may also be detrimental dependent on the circumstance, i.e., infection versus inflammation.

Type of Work:Ph.D. thesis.
Supervisor(s):Bosch, Jos and Burns, Victoria
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:Sport and Exercise Sciences
Subjects:RC Internal medicine
QR180 Immunology
BF Psychology
Institution:University of Birmingham
ID Code:845
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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